Cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime c. The average halflife in patients requiring hemodialysis was. Cefepime has an extended spectrum of activity against grampositive and gramnegative bacteria, with greater activity against both types of organism than thirdgeneration agents. Jul 24, 2018 cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime c 19 h 24 n 6 o 5 s 2 per mg, calculated on an anhydrous basis. Current shipping out time is about 2 weeks after order is received. Sds of cefepime hydrochloride, safety data sheets, cas. Coa, qc data and msds documents are available in one week after order is received. Cefepime hydrochloride 100 mg in poly bottle sigmaaldrich. If these medications are administered concurrently with cefepime, they should be administered at separate sites. Accidental release measures contain spill and collect, as appropriate. Cefepime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. Procedure inject a volume about 10 l of the test solution into the chromatograph, record the chromatogram, and measure the peak responses. To determine the stability of cefepime in peritoneal dialysis solution. Pbps are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell.
Cefepime binds to and inactivates penicillin binding proteins pbps located on the inner membrane of the bacterial cell wall. Maxipime for injection is supplied for intramuscular or intravenous administration in. Cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime c 19 h 24 n 6 o 5 s 2 per mg, calculated on an anhydrous basis. Cefepime total body clearance decreased proportionally with en3082 page 3 of 24. Cefepime cefepime injection, solution baxter healthcare corporationhighlights of prescribing information these highlights do not include all the information needed to use cefepime injection safely and effectively. The developed method was applied to the analysis of a cefepime sample and determined that nmp was present in a cefepime sample at a level of 0. Maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. Freshly constituted solutions of maxipime will range in color from colorless to amber.
The recommendations in this online publication do not indicate an exclusive course of treatment or serve as a standard of medical care. Dailymed cefepime cefepime hydrochloride injection. Cefepime is a fourthgeneration cephalosporin antibiotic developed in 1994. Maxipime cefepime hydrochloride, usp for injection fda. The average plasma concentrations of cefepime observed in healthy adult male volunteers n9 at various times following single 30minute infusions iv of cefepime 500 mg, 1 g, and 2 g are summarized in table 1. Variations, taking into account individual circumstances, may be. Cefepime has demonstrated clinical efficacy against a variety of infections, including urinary tract infections, pneumonia, and skin and skin structure infections. Cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime c 19 h 24 n 6 o 5 s 2 per mg, calculated. Cefepime binds to and inactivates penicillinbinding proteins pbps located on the inner membrane of.
Cefepime hcl is a cephalosporin antibiotic resistant to various. In vitro chromosome aberration chinese hamster ovary cho cells negative cefepime hydrochloride hydrate. Cefepime is the generic form of the brandname drug maxipime, which is used to treat bacterial infections such as urinary tract infections, pneumonia, and skin infections the prescription. Cefepime is a semisynthetic fourthgeneration cephalosporin. It is resistant to hydrolysis by common plasmid andor chromosomallymediated. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. Cefepime hydrochloride hydrate safety data sheet section 2. Methods and material for containment and cleaning up. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial. Oct 02, 2018 in clinical trials using multiple doses of cefepime, 47 patients were treated with the recommended dosages of cefepime 500 mg to 2 g intravenous every 12 hours. Cefepime hydrochloride injection, powder, for solution hospira, inc.
Cefepime maxipime side effects, dosage, interactions drugs. Cefepime is a fourthgeneration cephalosporin antibiotic. Chromatograph the system suitability solution, and record the peak responses as directed for procedure. Dailymed cefepime cefepime hydrochloride injection, powder. Cefepime pharmacokinetics have been investigated in patients with various degrees of renal impairment n30. Cefepime manufacturers, cefepime suppliers, cefepime.
See full prescribing information for cefepime injection. Cefepime is active against grampositive and gramnegative bacteria, with greater activity against both than thirdgeneration antibiotics. Baxter healthcare corporation cefepime cefepime injection. The addition of the hydrochloride salt enhances aqueous solubility. Treatment of complicated intraabdominal infections caused by escherichia coli, viridans streptococci, pseudomonas aeruginosa, klebsiella pneumoniae, enterobacter, or bacteroides fragilis. Cefepime is active against grampositive and gramnegative bacteria, with greater. For research use only, not for human or veterinary. Cefepime hydrochloride, chemical structure, molecular. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. The study is based on cefepime hydrochloride and magnesium the active ingredients of cefepime hydrochloride and magnesium oxide, respectively, and cefepime hydrochloride and magnesium oxide. Cefepime has potential for use as an antitumor agent, showing inhibition of human breast cancer cells in vitro when complexed with manganese.
The cefepime companies are offering top quality products. Cefepime hydrochloride c19h28cl2n6o6s2 cid 9571075 structure, chemical names, physical and chemical properties, classification, patents, literature. Cefepime cefepime injection, solution baxter healthcare corporationhighlights of prescribing information these highlights do not include all the information needed to use cefepime injection. Cefepime has potential for use as an antitumor agent, showing inhibition of human breast cancer cells in vitro when complexed with. Cefepime duplex 1gm 50ml hydrochloride and dextrose injection. Elimination of cefepime is principally via renal excretion with.
A 2007 metaanalysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other. Feb 22, 2018 cefepime hydrochloride hydrate mouse iv ld50 15002000mgkg in vitro chromosome aberration human lymphocytes positive material name. Cefepime hydrochloride drug information, professional. Cefepime has an extended spectrum of activity against grampositive and gramnegative bacteria, with greater activity against both types of organism. Cefepime hydrochloride api manufacturers pharmacompass. Application cefepime was used in antimicrobial susceptibility testing for acinetobacter baumannii and extendedspectrum. Material safety data sheet of cefepime d3 abmole bioscience. Maxipime cefepime hydrochloride dose, indications, adverse. Cefepime hydrochloride hydrate mouse iv ld50 15002000mgkg in vitro chromosome aberration human lymphocytes positive material name. Cefepime hcl was added to premade bags of delflex peritoneal dialysis solution with 1. Transfer to a chemical waste container for disposal in accordance with local regulations. Cefepime for injection usp and dextrose injection usp is a cephalosporin antibacterial indicated in the treatment of the following infections caused by susceptible strains of the designated microorganisms.
Maxipime for injection is supplied for intramuscular or intravenous. This medication is given by injection into a muscle or vein as directed by your doctor. Cefepime hydrochloride and dextrose information, side effects. W is the quantity, in mg, of cefepime hydrochloride taken to prepare the test solution. Side effects of maxipime cefepime hydrochloride for. Cefepime should not be added to ampicillin solutions of a strength greater than 40 mg per ml, or to aminophylline, gentamicin, metronidazole, netilmicin, tobramycin, or vancomycin solutions. There were no deaths or permanent disabilities thought related to drug toxicity. Cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile. Sigmaaldrich offers a number of cefepime hydrochloride products. Cefepime for injection usp and dextrose injection usp is a cephalosporin antibacterial indicated in the treatment of the following.
Pdf stability of cefepime in peritoneal dialysis solution. Cefepime hydrochloride monohydrate has a molecular mass of 571. The larginine, at an approximate concentration of 707 mgg of cefepime, is added to control the ph of the constituted. Oct 02, 2018 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. The nebraska medical center supporting evidence for alternate cefepime dosing substitution background cefepime cep is approved by the food and drug adminstration fda. Maxipime cefepime hydrochloride, usp for injection for. Cefepime has a pharmacokinetic disposition similar to that of other renally eliminated cephalosporins, with a halflife of approximately 2 hours. Material may be irritating to the mucous membranes and upper respiratory tract. Cefepime is a broadspectrum cephalosporin with enhanced coverage against grampositive and gramnegative bacteria. Cefepime maxipime side effects, dosage, interactions. Cefepime is a semisynthetic, broadspectrum, fourthgeneration cephalosporin with antibacterial activity. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial endocarditis associated with vascular cannulae or early less than 1 year after surgery prosthetic valve endocarditis. Cefepime hydrochloride is a white to pale yellow powder. Cefepime dihydrochloride monohydrate bacterial inhibitor.
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